Perturbation of SUMOlation Enzyme Ubc9 by Distinct Domain within Nucleoporin RanBP2/Nup358

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

FG-nucleoporin binding domain of Tap/NXF1

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain, which is based on a di...

متن کامل

Amyloid-like interactions within nucleoporin FG hydrogels.

The 62 kDa FG repeat domain of the nucleoporin Nsp1p forms a hydrogel-based, sieve-like permeability barrier that excludes inert macromolecules but allows rapid entry of nuclear transport receptors (NTRs). We found that the N-terminal part of this domain, which is characterized by Asn-rich inter-FG spacers, forms a tough hydrogel. The C-terminal part comprises charged inter-FG spacers, shows lo...

متن کامل

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.

While numerous small ubiquitin-like modifier (SUMO) conjugated substrates have been identified, very little is known about the cellular signalling mechanisms that differentially regulate substrate sumoylation. Here, we show that acetylation of SUMO E2 conjugase Ubc9 selectively downregulates the sumoylation of substrates with negatively charged amino acid-dependent sumoylation motif (NDSM) cons...

متن کامل

Balancing Domain Decomposition by Constraints and Perturbation

In this paper, we formulate and analyze a perturbed formulation of the BDDC method. We prove that the perturbed BDDC has the same polylogarithmic bound for the condition number as the standard formulation. Two types of properly scaled zero-order perturbations are considered: one uses a mass matrix and the other uses a Robin-type boundary condition, i.e, a mass matrix on the interface. With pert...

متن کامل

Analytical Solution of Steady State Substrate Concentration of an Immobilized Enzyme Kinetics by Laplace Transform Homotopy Perturbation Method

The nonlinear dynamical system modeling the immobilized enzyme kinetics with Michaelis-Menten mechanism for an irreversible reaction without external mass transfer resistance is considered. Laplace transform homotopy perturbation method is used to obtain the approximate solution of the governing nonlinear differential equation, which consists in determining the series solution convergent to the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2002

ISSN: 0021-9258

DOI: 10.1074/jbc.m104453200